Revised criteria included in a report recently published online first by the Archives of Neurology shows that many patients who are currently diagnosed with mild Alzheimer's disease dementia could possibly be reclassified as having mild cognitive impairment instead.
The results of the study suggest that 99.8 percent of patients who have been diagnosed with very mild AD dementia and 92.7 percent of those diagnosed with mild AD dementia could be reclassified and downgraded to MCI.
"The elimination of the functional boundary between MCI and AD dementia means that their distinction will be based solely on the individual judgment of clinicians, resulting in nonstandard and ultimately arbitrary diagnostic approaches to MCI," said Dr. John Morris, the study's author. "This recalibration of MCI moves its focus away from the earliest stages of cognitive decline, confounds clinical trials of individuals with MCI where progression to AD dementia is an outcome, and complicates diagnostic decisions and research comparisons with legacy data."
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